As one of the largest energy consumers worldwide, the transport sector accounts for about one quarter of global greenhouse gas emissions. Thus, to achieve the global climate targets, a systemic change of the mobility sector must be the next step in the global energy transition and a key concern of green recovery efforts. The high-level symposium Transforming Mobility by Mid-Century discusses the investment decisions that must be taken today to achieve decarbonization of our transport systems by 2050. Uniting mobility experts and policy makers from different countries, this panel discussion reflects on how we can enable this process by introducing new technologies and mobility models, increasing transport efficiency and incentivizing changes in mobility behavior as well as the role of e-mobility and hydrogen cells for future transport scenarios.